Brain-wide Neural Dynamics Lab

Understanding how the brain works is one of the defining scientific challenges of our time. With rapid advances in large-scale recording and artificial intelligence, neuroscience now stands at the edge of major breakthroughs. The Ye Lab follows a simple line of inquiry to uncover the brain’s organizing principles: from tools, to decoding, to manipulation. By coupling new recording technologies with computational analysis and causal perturbation, we aim to progress from observing brain-wide neural activity to understanding and ultimately shaping the brain.

We focus on three directions:

(1) exploring and building new brain-wide recording tools;

(2) uncovering the rules of sensorimotor processing and learning, with a particular focus on cross-modality integration and the functional logic of rotating waves;

(3) manipulating brain circuits causally to test mechanistic hypotheses and inform the treatment of brain disorders.